Open source
We build and openly share methods for measuring somatic evolution — from visualising clonal architecture to tracking subclones from circulating tumour DNA.
Visualising clonal heterogeneity
Creates visual representations of clonal heterogeneity within and across samples of an individual tumour, while preserving the underlying phylogenetic information. A compact way to see how subclones are distributed across regions and time.
Developed by Alex Frankell
Subclonal dynamics from ctDNA
Tracks tumour subclonal dynamics from low-fraction circulating tumour DNA (ctDNA), leveraging data from at least one matched tissue sample. Enables non-invasive, longitudinal reconstruction of how clones rise and fall under treatment.
Developed by Alex Frankell
Deconvolving whole-genome doubling
Deconvolves multiple subclonal whole-genome doubling (WGD) events within a single tumour from multiregional tissue sequencing. Parallel WGD events were unexpectedly found in ~20% of non-small cell lung tumours in TRACERx.
Developed by Alex Frankell
All of our tools are open source. If you use one in your work, please cite the associated publication (see Publications). Issues, questions and contributions are welcome on GitHub.
